Assay Development - Research Associate / Sr. Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful applicant will be involved in designing, executing and analyzing experiments to evaluate the diagnostic and therapeutic potential of drug candidates. The position requires excellent laboratory skills, critical thinking and attention to detail at the bench and the desk.

Primary Requirements:

1. Development, qualification and validation of cell-based and immunoassays assays
2. Prior hands-on experience with PK and ADA assays highly desirable
3. Experience transferring assays to a CRO and managing a CRO desirable
4. Experience with multicolor flow cytometry desirable
5. Experience with Western blotting and/ or IHC desirable
6. Experience isolating RNA and performing RT-PCR and qPCR assays
7. Knowledge of tumor biology and/ or stem cell biology desirable

Qualifications:

1. Bachelors degree in a scientific discipline with a minimum of 3 years experience or,
2. Masters degree in a scientific discipline
3. Strong attention to detail
4. Ability to work independent with minimal supervision
5. Ability to analyze data and document results
6. Ability to adapt to changing priorities
7. GLP work history
8. Strong communication skills (verbal, written, interpersonal, listening)
9. Strong mathematical skills
10.Time management (schedules, timelines, task prioritization)
11.Excellent problem-solving skills; solution-oriented
12.Team oriented
13.Perform other related duties as required

Assay Development - Research Associate / Sr. Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful applicant will be involved in designing, executing and analyzing assays to evaluate the diagnostic and therapeutic potential of drug candidates. This position will support early discovery research as well as pre-IND development activities. The Assay Development team is seeking an individual who is highly motivated, collaborative, and adaptable with excellent communication skills.

Primary Requirements:

1. Support Stem CentRx discovery research efforts by developing and performing assays to evaluate biologic drug candidates, often using cell-based and ELISA assays
2. Perform pharmacokinetic and other bioanalytical assays to support pre-IND activities
3. Data analysis and presentation in department and project team meetings
4. Detail oriented notebook entry

Qualifications:

1. Bachelors degree in a scientific discipline with a minimum of 1-3 years experience or,
2. Masters degree in a scientific discipline with 0-1 years experience
3. Mammalian cell culture and cell based assay experience
4. Flow cytometry and other methods of protein detection (ELISA, WB, IP)
5. Excellent time management and ability to multi-task
6. Excellent oral and written communication skills
7. Collaborative, team oriented
8. Ability to adapt to changing priorities
9. Familiarity with antibody drug conjugates desirable
10. Experience in assay qualification and validation desirable

Antibody Discovery - Research Associate / Scientist

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to antibody and recombinant protein expression, purification and validation. The successful candidate will be responsible for purification of recombinant protein antigens as deliverables for immunization campaigns, hybridoma screening, antibody preparation and determination of antibody affinity and kinetics for antigen as a means to choose an optimal therapeutic. The ability to work independently, while effectively interacting and communicating with the research group and external collaborators, is a prerequisite.

Requirements:

1. BS in Biology or Engineering with 2+ years of relevant research experience
2. PhD in Biology with 2+ years of relevant research experience
3. Experience with Biacore, ForteBIO and/or other methods for biophysical measurements
4. Hands-on experience in protein purification preferred
5. Hands-on experience in flow cytometry/FACS a plus
6. Flexibility to learn techniques and accomplish goals outside those stated above
7. Ability to multitask and meet deadlines in a fast-paced environment
8. Organized and disciplined record keeping
9. Excellent personality, problem solving and communication skills

In Vivo Biology - Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will help perform in vivo experiments. Duties include, but are not limited to, constructing tumor xenograft models, weekly tumor measurements, administering therapeutic agents through various routes, organizing data, and analyzing results. The successful candidate will be expected to efficiently monitor effects of therapeutic agents on tumor growth, metastasis, survival, and overall animal health. The position may also involve assisting with other tasks in the vivarium and/or participate in other exciting areas of research when time permits.

Requirements:

1. Minimum 2-5 years of directly related experience. AALAS certification is preferred but not required
2. Ability to multitask and meet deadlines in a fast-paced environment
3. Organized and disciplined about record keeping, with proficiency in Microsoft Office
4. Able to perform occasional physical labor involving lifting weight up to 50 pounds
5. Willing to split weekend and holiday hours with co-workers on a rotational basis
6. Excellent verbal and written communication skills
7. Strong organizational skills, motivated to excel, attentive to detail, and can be efficient working alone or in a group environment

Molecular Biology - Sr Research Associate / Scientist

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will spearhead execution of Molecular Biology cloning efforts. In this role he/she will: a) serve as a key team member in the production of expression and lentiviral vectors as required by the company, particularly those encoding non-human proteins; b) assist other members of the Molecular Biology group in various analyses of gene expression as required; and c) analyze data and communicate results to the Molecular Biology group and to the company in both oral and written form. Candidates must have a strong desire to work in a dynamic team environment and aggressively contribute to the company’s growth and mission.

Requirements:

1. Ph. D. level scientist with 3+ years, or non Ph. D scientist with 6+ years of molecular biology experience, with preference given to industrial experience or environments requiring significant numbers of construct deliverables on tight timelines
2. Mandatory technical skills include demonstrable proficiency in molecular cloning strategies, particularly in the design of efficient and quick routes to obtaining the desired clones, using combinations of commercial clones, cloning from RNA or cDNA sources, multisite mutagenesis, and/or design of synthetic genes and/or gene fragments as required
3. Experience purifying RNA and working with RNA/cDNAs as a source of material for cloning required
4. Experience in working with various public genomic databases, comparative sequence analysis, and a good conceptual understanding of protein domains strongly preferred
5. Experience with techniques for analysis of expression levels of genes and proteins (e.g., RT-PCR, immunoblotting, flow cytometry) beneficial
6. Mandatory professional skills include organized and disciplined record keeping, excellent communication skills, an ability to work effectively with others in a dynamic environment, and the ability to self-motivate, multitask, and meet frequently tight deadlines

Procurement Specialist / Buyer

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be responsible for the timely planning and procurement of requested items in order to meet deadlines while complying with applicable procedures, policies, and regulations. To achieve this, the procurement specialist / buyer will communicate regularly with scientists to generate and manage purchase orders, maintain procurement records and track outstanding orders. The candidate should have a personality to develop and maintain strong relationships with suppliers and vendors to improve costs and drive savings.

General Purchasing Operations:

- Accept internal purchasing requisitions to generate and execute on all purchase orders
- Log and track all outstanding orders, updating colleagues as appropriate on the status of their order
- Work with receiving to reconcile deliveries, processing any returns and addressing incompletes
- Look to automate as much of the general ordering and inventory evaluation process as possible

Capital Equipment Procurement:

- Assist scientists in the sourcing and procurement of equipment to support existing asset requirements and future expansion, negotiating pricing with vendors as appropriate
- Work with receiving to track and coordinate delivery of new equipment purchased
- Assist Facilities in executing renewal of essential service contracts, ensuring no coverage lapses

Requirements:

1. Education: Bachelor’s Degree preferred
2. Previous work in procurement, receiving, and inventory management
3. Biotech, pharmaceutical or scientific research industry preferred
4. Knowledge of forecasting, master scheduling, resource planning
5. Independent and industrious personality
6. Excellent communication skills and ability to work in team-oriented environment
7. Basic understanding of mechanics to perform routine maintenance/repair of lab equipment a plus
8. Highly organized & disciplined in completing tasks on time