Careers

Stem CentRx ™ is focused on scientific discovery and development of successful cancer drugs. We are funded by scientists and entrepreneurs with a long-term perspective on our business. Our culture is an apolitical meritocracy where performance and teamwork are rewarded. Stem CentRx has assembled a talented and motivated team, and is looking to recruit additional employees with world-class expertise in their practice, versatility to contribute broadly across the company, high energy and an entrepreneurial spirit.

Bioinformatics / IT - Bioinformatics Analyst

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to the team by participating in the development of strategies and techniques for statistical analysis of expression data, pathways analysis, and potentially working closely with a biomarker/diagnostics scientist on related projects involving public and private clinical data. The ability to work independently, while effectively interacting and communicating with other team members, is also prerequisite. Consideration will be given to strong candidates with lesser experience.

Requirements:

1. A bioinformatics, biostatistics or related graduate degree
2. 2+ years of experience is preferred
3. Technical experience using/scripting in R/Biocondcutor, BioPerl or BioPython
4. Familiarity with command-line UNIX/Linux
5. Ability to multitask and work in a fast-paced environment
6. Motivated, organized and disciplined record keeping
7. Great personality and excellent communication skills
8. Strong track record of achievement and advancement desired

Bioinformatics / IT - Software Developer

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to the team by participating in the development of custom web based software for use by scientists. The ability to work independently, while effectively interacting and communicating with other team members, is also prerequisite.

Requirements:

1. A computer science or related bachelor’s degree or 2-5 years of experience
2. Technical experience in one of Ruby, RoR, Java, Grails
3. Experience working with Tableau is a plus
4. Experience with a code management system, preferably Git
5. Ability to multitask and work in a fast-paced environment
6. Motivated, organized and disciplined record keeping
7. Great personality and excellent communication skills
8. Strong track record of achievement and advancement desired

Antibody Discovery - Sr. Research Associate / Associate Scientist / Scientist

Description

As part of a talented, multi-disciplinary and passionate team advancing an exciting new approach to drug discovery and development, we are looking for highly motivated candidates who will spearhead execution of therapeutic antibody generation using hybridoma and other related technologies in the Antibody Discovery group at Stem CentRx.

The ideal candidate would have hands-on experience across the broad spectrum of work involved, i.e. hybridoma technology, electrofusions, flow cytometry, single-cell cloning, antigen conjugations and cell biology assay development using automation.

This scientist will design immunization strategies for simple to highly complex targets, perform B-cell isolation, enrichment and fusions, in addition to devising and executing high-throughput automated screening approaches to select high quality drug candidates. The successful candidate should have the ability to integrate the requirements dictated by the biology of targets in the generation of antibody therapeutics and have considerable experience in troubleshooting issues arising during any phase of projects.

The scientist must be able to proactively communicate with cross-functional teams to obtain support for antibody therapeutic generation, antigen source or functional screening, and will be expected to stay on top of current trends in hybridoma processes so as to implement new processes and efficiencies if beneficial.

Requirements:

1. Our ideal candidate should have a Ph.D. with 0-2 years, MS or BS with 4-6 years of experience in Cellular Biology, Immunology, Biochemistry, or a related field, with at least 2 years of biotech experience in the therapeutic antibody generation field.
2. Must have hands-on in-depth experience in hybridoma technology and good understanding in basic immunology, molecular biology, and antibody discovery.
3. Significant knowledge and experience with high throughput screening assay development preferably utilizing Beckman, Hamilton or Tecan robotics. Experience with flow cytometry and ELISAs is highly preferred.
4. Experience with FACS sorting, antibody expression, antigen conjugations and purification is highly preferred.
5. Candidates should be detail-oriented, possess excellent organizational and communication skills, and able to multitask across several scientific areas. The candidate should be able to work as part of a team, while at the same time have the proven ability to independently plan and direct projects to completion within required timelines.

ADC Technology - Research Associate / Senior Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to oncology drug discovery and development, the successful candidate will participate in both early and late stage synthetic chemistry efforts aimed at identifying and developing novel linker/payload technologies for preclinical evaluation and clinical use. In this role, he/she will synthesize, purify and characterize biologically-active organic small molecules and natural products and execute the synthesis of novel linkers and payloads for bioconjugation.

The successful candidate must be able to excel in the execution of techniques common to synthetic organic chemistry, and be comfortable with reactions at all scales of synthesis. Experience with purification method development (both normal and reverse phase) for complex mixtures is a plus. Experience with natural product and complex heterocycle syntheses is essential, as is a strong desire to work in a dynamic Team environment and aggressively contribute to the company’s growth and mission.

Requirements:

1. BS or MSc in Synthetic Organic Chemistry.
2. Experience in the synthesis of natural products and complex heterocycles.
3. Ability to execute common spectroscopic and analytical techniques (NMR, MS, HPLC, IR).
4. Experience in the synthesis of peptides and peptidomimetics is a plus.
5. Experience in cGMP manufacturing is a plus.
6. Organized and disciplined record keeping.
7. Ability to multitask and meet deadlines in a fast-paced environment is essential.

Molecular Pathology (Histotechnologist) - Research Associate / Senior Research Associate

Description

As part of a talented, multi-disciplinary, and passionate team advancing an exciting new approach to drug discovery and development, we are looking for a highly motivated and passionate candidate to spearhead the development and operation of a top notch histology laboratory to support both pre-clinical and clinical activities.

The ideal candidate should have hands-on histology experience grossing, processing and embedding tissues, preparing sections from frozen and FFPE tissues and immunostaining tissues with a variety of reagents and building tissue micro-arrays. The successful candidate will be responsible for setting up a world-class histology lab by identifying and organizing the purchase of capital equipment, manage specimen lifecycle from necropsy to sectioning, organize implementation of barcoded sample tracking and become a primary contact for sourcing of human FFPE tissues from collaborators and commercial sources. The candidate will also be required to establish histology SOPs and coordinate protocol development and study design across departments. Exceptional histopathology knowledge in human, rodent and xenograft tumor models is a must.

Requirements:

1. Bachelor’s degree in a relevant scientific field, with a minimum of 5 years industry experience
2. ASCP HT certification
3. Demonstrated ability to proactively communicate with cross-functional teams and stay abreast of current trends in pathology so as to implement new processes and efficiencies if beneficial.

Molecular Pathology - Scientist

Description

As part of a talented, multi-disciplinary, and passionate team advancing an exciting new approach to drug discovery and development, we are looking to hire a highly motivated candidate to join our molecular pathology group.

The ideal candidate will have substantial experience with slide-based assays on FFPE tissues such as immunohistochemistry, in-situ hybridization, and dual labeling of both assay formats in chromagen and fluorescence detection. The successful candidate will utilize image analysis for quantification of target expression and should have strong knowledge of slide-based assay development for companion diagnostics development. Advanced knowledge of human solid tumors, normal human primate tissue and xenograft tumor model histology is a must. Ability to independently design and execute complex experiments, analyze and present data is also a must.

Requirements:

1. Bachelor’s degree in a relevant scientific field with a minimum of 8 years industry experience, or a Ph. D with a minimum of 4 years experience
2. The candidate must be able to proactively communicate across functional teams and stay abreast of current trends in pathology so as to evaluate and implement new processes and efficiencies

CV / Resume

hr@stemcentrx.com
Please include the group name in the subject line of the email so that your resume is forwarded properly to the hiring manager.

Current Open Positions:

Antibody Discovery
Sr. Research Associate / Associate Scientist / Scientist

ADC Technology
Research Associate / Senior Research Associate

Bioinformatics / IT
Bioinformatics Analyst
Software Developer

Molecular Pathology
Scientist
Research Associate / Senior Research Associate