Careers

Stem CentRx ™ is focused on scientific discovery and development of successful cancer drugs. We are funded by scientists and entrepreneurs with a long-term perspective on our business. Our culture is an apolitical meritocracy where performance and teamwork are rewarded. Stem CentRx has assembled a talented and motivated team, and is looking to recruit additional employees with world-class expertise in their practice, versatility to contribute broadly across the company, high energy and an entrepreneurial spirit.

Bioinformatics / IT - Bioinformatics Analyst

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to the team by participating in the development of strategies and techniques for statistical analysis of expression data, pathways analysis, and potentially working closely with a biomarker/diagnostics scientist on related projects involving public and private clinical data. The ability to work independently, while effectively interacting and communicating with other team members, is also prerequisite. Consideration will be given to strong candidates with lesser experience.

Requirements:

1. A bioinformatics, biostatistics or related graduate degree
2. 2+ years of experience is preferred
3. Technical experience using/scripting in R/Biocondcutor, BioPerl or BioPython
4. Familiarity with command-line UNIX/Linux
5. Ability to multitask and work in a fast-paced environment
6. Motivated, organized and disciplined record keeping
7. Great personality and excellent communication skills
8. Strong track record of achievement and advancement desired

Bioinformatics / IT - Software Developer

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to the team by participating in the development of custom web based software for use by scientists. The ability to work independently, while effectively interacting and communicating with other team members, is also prerequisite. Consideration will be given to strong candidates with lesser experience.

Requirements:

1. A computer science or related bachelor’s degree or1 year of experience
2. Technical experience in one of Ruby, RoR, Java, Grails
3. Experience working with Tableau is a plus
4. Experience with a code management system, preferably Git
5. Ability to multitask and work in a fast-paced environment
6. Motivated, organized and disciplined record keeping
7. Great personality and excellent communication skills
8. Strong track record of achievement and advancement desired

Bioprocess Development - Associate Scientist (BPD001)

Duties:

Support all aspects of process development for monoclonal antibodies and Antibody Drug Conjugation (ADC). Specifically, perform assay development and characterization, purification and conjugation of research materials for in-vivo efficacy and non GLP/GLP tox studies. Develop in-process analytics of mAbs and ADCs. Perform development, execution, technology transfer of modification, conjugation, and purification processes for ADCs. Collaborate with other departments including Cell Culture, Purification, Formulation /Analytical Development, Manufacturing, Quality, Regulatory and Research/Discovery/Development groups.

Education Required:

Bachelor’s degree or foreign equivalent in Chemical Engineering or a related field.

Experience Required:

5 years of progressive post-baccalaureate experience in job offered or as an Engineer, Co-op Engineer, R&D intern, or related.

Special Requirements:

Experience required in the following:
1. Developing and characterizing monoclonal antibody (mAb) purification processes using chromatography, normal flow and tangential flow filtration, and centrifugation
2. Antibody Drug Conjugation (ADC) process development, including knowledge of redox chemistry and linker-drug technologies
3. AKTA, HPLC, UPLC, and UV-Vis spectrophotometry based laboratory equipment and techniques
4. Working in a cGMP (current good manufacturing practices for human pharmaceuticals) environment
5. Monoclonal antibody (mAb)and Antibody Drug Conjugation (ADC) process tech transfer
6. On-floor support for execution of GMP mAb monoclonal antibody and Antibody Drug Conjugation (ADC) batches including providing technical expertise for the assessment of manufacturing discrepancies and deviations; and
7. Contributing to regulatory filings for biologic therapeutics such as IND (investigational new drug filing) or BLA (biologics license application).

Worksite:

450 E. Jamie Court, 3rd Floor, S. San Francisco, CA 94080

Cancer Biology - Research Associate / Sr. Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, Stem CentRx is looking to hire a Research Associate or Senior Research Associate with experience in stem cell biology and oncology drug discovery. The successful candidate will work as part of a Team to leverage Stem CentRx’s assets to facilitate discovery and validation of cancer stem cell-associated therapeutic targets and develop circulating tumor cell-associated companion diagnostics in support of clinical drug candidates. The successful applicant will also be expected to introduce best practices from past experiences to enrich Stem CentRx’s scientific discovery and company culture.

The candidate must have a strong desire to work in a dynamic Team environment and aggressively contribute to the company’s growth and mission.

Requirements:

1. BS or equivalent degree in biology or a related field, with 3+ years of relevant academic and/or industry experience
2. Demonstrated skill at multicolor flow cytometry, RNA handling, and qRT-PCR
3. Experienced in tissue culture, cell based assays, and proficiency handling blood and working with small cell numbers desired
4. Ability to multitask and meet deadlines in a fast-paced environment
5. Motivated, proactive, organized, and disciplined at record keeping
6. Great personality and excellent communication skills are essential

Manufacturing - Manufacturing Technical Specialist (Job code #BG1)

Duties:

Responsible for the setup, operation, and maintenance of the laboratory equipment used to produce the drug. Includes monitoring the equipment, calculating quantities produced and recording the results of the production process. Responsible for the setup, testing, qualification and operation of bioprocess equipment such us Bioreactors, TFF and chromatography in a GMP facility. Responsible for the creation of process specific documents (SOPs, Batch Records) needed for the execution of clinical campaigns. Work on projects related to facility startup including equipment set up, trouble shooting, protocol creation, equipment qualification and overall operations (maintenance, cleaning) for the new biotech facility.Collaborate with the product development group in the development of new drugs and scale up to clinical manufacturing.

Education Required:

Bachelor’s degree or foreign equivalent in Chemical Engineering, Biomedical Engineering or related.

Experience Required:

5 years of experience in Technical Specialist, Technician, or related occupations

Alternate Requirements:

Will accept no degree and 7 years of experience in Technical Specialist, Technician, or related occupations

Special Requirements:

Experience in GMP production and Biotech Process Development required. Must have experience writing GMP documents, SOPs, and batch records. Must have experience with cell culture and harvest processes as well as with single use systems. Experience in purification and formulation along with knowledge of column chromatography and tangential flow filtration is required. Must have experience managing technicians and on-the-floor operations. Must have experience with facility start up and equipment qualification / validation.

Worksite:

450 E. Jamie Ct, 3rd Floor, S. San Francisco, CA 94080

CV / Resume

hr@stemcentrx.com
Please include the group name in the subject line of the email so that your resume is forwarded properly to the hiring manager.

Current Open Positions:

Bioinformatics / IT
Bioinformatics Analyst
Software Developer

Bioprocess Development
Associate Scientist

Cancer Biology
Research Associate / Sr. Research Associate

Manufacturing
Manufacturing Technical Specialist