Careers

Stem CentRx ™ is focused on scientific discovery and development of successful cancer drugs. We are funded by scientists and entrepreneurs with a long-term perspective on our business. Our culture is an apolitical meritocracy where performance and teamwork are rewarded. Stem CentRx has assembled a talented and motivated team, and is looking to recruit additional employees with world-class expertise in their practice, versatility to contribute broadly across the company, high energy and an entrepreneurial spirit.

Bioinformatics / IT - Bioinformatics Analyst

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to the team by participating in the development of strategies and techniques for statistical analysis of expression data, pathways analysis, and potentially working closely with a biomarker/diagnostics scientist on related projects involving public and private clinical data. The ability to work independently, while effectively interacting and communicating with other team members, is also prerequisite. Consideration will be given to strong candidates with lesser experience.

Requirements:

1. A bioinformatics, biostatistics or related graduate degree
2. 2+ years of experience is preferred
3. Technical experience using/scripting in R/Biocondcutor, BioPerl or BioPython
4. Familiarity with command-line UNIX/Linux
5. Ability to multitask and work in a fast-paced environment
6. Motivated, organized and disciplined record keeping
7. Great personality and excellent communication skills
8. Strong track record of achievement and advancement desired

Bioinformatics / IT - Software Developer

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will be expected to contribute to the team by participating in the development of custom web based software for use by scientists. The ability to work independently, while effectively interacting and communicating with other team members, is also prerequisite.

Requirements:

1. A computer science or related bachelor’s degree or 2-5 years of experience
2. Technical experience in one of Ruby, RoR, Java, Grails
3. Experience working with Tableau is a plus
4. Experience with a code management system, preferably Git
5. Ability to multitask and work in a fast-paced environment
6. Motivated, organized and disciplined record keeping
7. Great personality and excellent communication skills
8. Strong track record of achievement and advancement desired

ADC Technology - Research Associate / Senior Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to oncology drug discovery and development, the successful candidate will participate in both early and late stage synthetic chemistry efforts aimed at identifying and developing novel linker/payload technologies for preclinical evaluation and clinical use. In this role, he/she will synthesize, purify and characterize biologically-active organic small molecules and natural products and execute the synthesis of novel linkers and payloads for bioconjugation.

The successful candidate must be able to excel in the execution of techniques common to synthetic organic chemistry, and be comfortable with reactions at all scales of synthesis. Experience with purification method development (both normal and reverse phase) for complex mixtures is a plus. Experience with natural product and complex heterocycle syntheses is essential, as is a strong desire to work in a dynamic Team environment and aggressively contribute to the company’s growth and mission.

Requirements:

1. BS or MSc in Synthetic Organic Chemistry.
2. Experience in the synthesis of natural products and complex heterocycles.
3. Ability to execute common spectroscopic and analytical techniques (NMR, MS, HPLC, IR).
4. Experience in the synthesis of peptides and peptidomimetics is a plus.
5. Experience in cGMP manufacturing is a plus.
6. Organized and disciplined record keeping.
7. Ability to multitask and meet deadlines in a fast-paced environment is essential.

Cancer Biology - Research Associate

Description

Stem CentRx is looking to hire a Research Associate for its Cancer Biology group. The successful candidate will become part of a talented and multi-disciplinary team advancing an exciting new approach to oncology drug discovery and development. In this role, the candidate will process human and animal tissue for isolation of cells, perform cell-based assays, and participate in both the development of preclinical in vivo models and early stage target discovery/validation.

The candidate must have a strong desire to work in a dynamic team environment, aggressively contribute to the company’s growth and mission, and be a catalyst to enable the development and approval of oncology drugs that significantly improve patient survival.

Requirements:

1. Minimum of BS in life science with at least 1-2 years hands-on laboratory experience.
2. Demonstrated proficiency to work aseptically in tissue culture and processing tissue samples for further analysis or cell isolation.
3. Experience with antibody-based assays and flow cytometry are highly desired.
4. Must be willing to work with in vivo models.
5. Ability to multitask and meet deadlines in a fast-paced environment.
6. Motivated, organized and disciplined record keeping.
7. Exceptional verbal and written communication skills are essential.

In Vivo Biology - Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful candidate will help perform in vivo experiments. Duties include, but are not limited to, constructing tumor xenograft models, weekly tumor measurements, administering therapeutic agents through various routes, organizing data, and analyzing results. The successful candidate will be expected to efficiently monitor effects of therapeutic agents on tumor growth, metastasis, survival, and overall animal health. The position may also involve assisting with other tasks in the vivarium and/or participate in other exciting areas of research when time permits.

Requirements:

1. Minimum 2-5 years of directly related experience. AALAS certification is preferred but not required
2. Ability to multitask and meet deadlines in a fast-paced environment
3. Organized and disciplined about record keeping, with proficiency in Microsoft Office
4. Able to perform occasional physical labor involving lifting weight up to 50 pounds
5. Willing to split weekend and holiday hours with peers on a rotational basis
6. Excellent verbal and written communication skills
7. Strong organizational skills, motivated to excel, attentive to detail, and can be efficient working alone or in a group environment

Molecular Pathology (Histotechnologist) - Research Associate / Senior Research Associate

Description

As part of a talented, multi-disciplinary, and passionate team advancing an exciting new approach to drug discovery and development, we are looking for a highly motivated and passionate candidate to spearhead the development and operation of a top notch histology laboratory to support both pre-clinical and clinical activities.

The ideal candidate should have hands-on histology experience grossing, processing and embedding tissues, preparing sections from frozen and FFPE tissues and immunostaining tissues with a variety of reagents and building tissue micro-arrays. The successful candidate will be responsible for setting up a world-class histology lab by identifying and organizing the purchase of capital equipment, manage specimen lifecycle from necropsy to sectioning, organize implementation of barcoded sample tracking and become a primary contact for sourcing of human FFPE tissues from collaborators and commercial sources. The candidate will also be required to establish histology SOPs and coordinate protocol development and study design across departments. Exceptional histopathology knowledge in human, rodent and xenograft tumor models is a must.

Requirements:

1. Bachelor’s degree in a relevant scientific field, with a minimum of 5 years industry experience
2. ASCP HT certification
3. Demonstrated ability to proactively communicate with cross-functional teams and stay abreast of current trends in pathology so as to implement new processes and efficiencies if beneficial.

Molecular Pathology - Scientist

Description

As part of a talented, multi-disciplinary, and passionate team advancing an exciting new approach to drug discovery and development, we are looking to hire a highly motivated candidate to join our molecular pathology group.

The ideal candidate will have substantial experience with slide-based assays on FFPE tissues such as immunohistochemistry, in-situ hybridization, and dual labeling of both assay formats in chromagen and fluorescence detection. The successful candidate will utilize image analysis for quantification of target expression and should have strong knowledge of slide-based assay development for companion diagnostics development. Advanced knowledge of human solid tumors, normal human primate tissue and xenograft tumor model histology is a must. Ability to independently design and execute complex experiments, analyze and present data is also a must.

Requirements:

1. Bachelor’s degree in a relevant scientific field with a minimum of 8 years industry experience, or a Ph. D with a minimum of 4 years experience
2. The candidate must be able to proactively communicate across functional teams and stay abreast of current trends in pathology so as to evaluate and implement new processes and efficiencies

Assay Development - Research Associate / Senior Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful applicant will be involved in designing, executing and analyzing experiments to evaluate the behavior of novel drug candidates in vivo in a regulated setting. The position requires excellent laboratory skills, critical thinking, and attention to detail at the bench and the desk.

Primary Responsibilities:

1. Development and validation of ligand-binding assays for PK and immunogenicity analysis
2. Development of standard operating procedures
3. Testing in a regulated environment
4. Assist in maintaining testing lab in a compliant state
5. Perform other related duties as required

Qualifications:

1. Bachelors degree in a scientific discipline with a minimum of 3 years’ experience or,
2. Masters degree in a scientific discipline
3. Demonstrated experience developing and performing ligand-binding assays for PK and immunogenicity
4. Prior GLP or GMP testing experience desirable
5. Knowledge of tumor biology and/ or stem cell biology desirable
6. Strong attention to detail
7. Ability to work independently with minimal supervision
8. Ability to analyze data and document results
9. Ability to adapt to changing priorities
10. Strong communication skills (verbal, written, interpersonal, listening)
11. Strong mathematical skills
12. Time management (schedules, timelines, task prioritization)
13. Excellent problem-solving skills; solution-oriented
14. Team oriented

Experience with any of the following techniques is a plus:

1. Immunofluorescence
2. Multicolor flow cytometry
3. Western blotting
4. Study sample management

Assay Development - Research Associate / Senior Research Associate

Description

As part of a talented and multi-disciplinary team advancing an exciting new approach to drug discovery and development, the successful applicant will be responsible for evaluating antibodies and antibody drug conjugates using cell and ELISA based techniques. The position requires cell culture laboratory skills, experience with various ELISA platforms and an understanding of antibody biology and structure. Flow cytometry experience is highly desirable. It is essential that applicants are highly organized and able to multitask effectively.

Primary Responsibilities:

1. Characterization of antibodies utilizing cell and ELISA based assays including cytotoxicity, internalization, antibody binning
2. Protein expression profiling
3. Optimization and development of new assays as appropriate
4. May include generation of data for IND submissions and report writing depending on experience
5. Presentation of data to project teams and preparation of data for patents

Qualifications:

1. Bachelor’s degree in a scientific discipline with a minimum of 3-5 years’ experience or,
2. Master’s degree in a scientific discipline.
3. Demonstrated experience developing and performing cell and ELISA based assays
4. Knowledge of flow cytometry, MSD, and Luminex platforms desirable
5. Knowledge of tumor biology and/ or stem cell biology desirable
6. Knowledge of antibody PK and ADA assays desirable
7. Strong attention to detail and organization
8. Ability to work independently with minimal supervision
9. Ability to analyze data and document results
10. Ability to adapt to changing priorities
11. Strong communication skills (verbal, written, interpersonal, listening)
12. Strong mathematical skills
13. Time management (schedules, timelines, task prioritization)
14. Excellent problem-solving skills; solution-oriented
15. Team oriented

Experience with any of the following techniques is a plus:

1. Immunofluorescence/High Content Imaging
2. Multicolor flow cytometry
3. Software including IDBS E-workbook, PRISM, FlowJo

CV / Resume

hr@stemcentrx.com
Please include the group name in the subject line of the email so that your resume is forwarded properly to the hiring manager.

Current Open Positions:

ADC Technology
Research Associate / Senior Research Associate

Assay Development
Research Associate / Senior Research Associate
Research Associate / Senior Research Associate

Bioinformatics / IT
Bioinformatics Analyst
Software Developer

Cancer Biology
Research Associate

In Vivo Biology
Research Associate

Molecular Pathology
Scientist
Research Associate / Senior Research Associate